ChIPCodis: mining complex regulatory systems in yeast by concurrent enrichment analysis of chip-on-chip data

نویسندگان

  • Federico Abascal
  • Pedro Carmona-Saez
  • José María Carazo
  • Alberto D. Pascual-Montano
چکیده

MOTIVATION Eukaryotic genes are often regulated by multiple transcription factors (TFs). Depending on the interactions among different TFs the expression of a gene can be tuned to respond to diverse environmental conditions. Chip-on-chip experiments provide a snapshot of which TF are in vivo bound to which genes in a particular condition, and have been applied to characterize the regulatory code of yeast under several experimental settings. ChIPCodis mines this data to provide new insights about how the expression of a particular group of genes is regulated. For a given list of yeast genes ChIPCodis determines which combinations of TFs are significantly over-represented in a series of environmental conditions. AVAILABILITY http://chipcodis.dacya.ucm.es

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عنوان ژورنال:
  • Bioinformatics

دوره 24 9  شماره 

صفحات  -

تاریخ انتشار 2008